Abemaciclib

Category Pipeline APIs

Details	Specifications
CAS Number	1231929-97-7
Molecular Formula	C27H32F2N8
Molecular Weight	506.61 g/mol.
Synonyms	5-(4-ethylpiperazin-1-ylmethyl) pyridin-2-yl) -(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl) pyrimidin-2-yl) amine
Chemical Name	N-[5-[ (4-ethyl-1-piperazinyl) methyl]-2-pyridinyl]-5-fluoro-4-[4 fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]
Therapeutic use	Breast cancer, Endocrine therapy, cyclin-dependent kinase (CDK) inhibitors.
Status	Tech pack available
Background	Abemaciclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). These kinases are activated upon binding to D-cyclins. In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4/6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation.
Grade	In-house
Polymorph	Form III
Storage Temperature	Controlled room temperature (20?C ? 25?C)

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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