Tenofovir Alafenamide Hemifumarate

Category API

Details	Specifications
CAS Number	1392275-56-7
Molecular Formula	C23H31N6O7P
Molecular Weight	534.5 g/mol.
Synonyms	(S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl) propan-2-yl) oxy) methyl) (phenoxy)phosphoryl) amino) propanoate hemi fumarate
Chemical Name	Isopropyl (S)-((((R)-1-(6-amino-9H-purin-9-yl) propan-2-yl) oxy) methyl) (phenoxy)phosphoryl-L-alaninate hemi fumarate
Common name	Tenofovir Alafenamide Hemi fumarate
Therapeutic use	Chronic Hepatitis B (HBV) and HIV-1
Background	Tenofovir alafenamide hemi fumarate (TAF) is a novel, targeted prodrug of the nucleotide reverse transcriptase inhibitor (NRTI). Approved for HIV in the U.S. in 2015. Approved for chronic HBV in the U.S. in 2016 (Vemlidy). Approved in multiple other regions including Canada and the EU (as generic combination)
Grade	In-house
Polymorph	Form-STA
GTI	Risk assessment report available
Nitrosamines	Risk assessment report available
DMF Availability	USDMF# 33850
Manufacturing batch size	10.0 Kg
Production capacity	Annual capacity is 2.0 – 2.2 tonnes
Stability data	Available

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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