Encorafenib

Category
Details
Specifications
CAS Number
1269440-17-6
Molecular Formula
C22H27ClFN7O4S
Molecular Weight
540.01 g/mol.
Synonyms
(S)-methyl(1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido) phenyl)-1-isopropyl-1H-pyrazol-4-yl) pyrimidin-2-yl) amino) propan-2-yl) carbamate
Chemical Name
(S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methyl sulfonamido) phenyl)-1-isopropyl-1H-pyrazol-4-yl) pyrimidin-2-yl) amino) propan-2-yl) carbamate
Therapeutic use
Antimetabolite chemotherapy, Chemotherapy for pancreatic lung cancer, breast cancer and bladder cancer.
Status
Tech pack available
Background
Encorafenib (brand name Braftovi) is an oral, small-molecule kinase inhibitor designed to target and inhibit the activity of mutated BRAF proteins, specifically the V600E and V600K mutations. These mutations are key drivers of cancer growth, leading to constitutive activation of the MAPK signaling pathway, which is common in approximately 50% of melanomas.
Grade
In-house
Polymorph
Form A and Amorphous
Storage Temperature
Form A: Controlled room temperature (20?C ? 25?C) | Amorphous: Controlled temperature at 2?C ? 8?C.

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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