Axitinib

Category API

Details	Specifications
CAS Number	319460-85-0
Molecular Formula	C22H18N4OS
Molecular Weight	386.47 g/mol.
Synonyms	(E)-N-Methyl-2-(3-(2-pyridin-2-yl) vinyl)-1H-indazol-6-yl)thio)benzamide
Chemical Name	(E)-N-Methyl-2-(3-(2-pyridin-2-yl) vinyl)-1H-indazol-6-yl)thio)benzamide
Common name	Axitinib
Therapeutic use	-
Background	Small molecule [tyrosine kinase inhibitor](https://www.google.com/search?q=tyrosine+kinase+inhibitor&oq=axitinib+Therapeutic+use+%2FDrug+class&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigAdIBCDg5OTBqMGo3qAIAsAIA&sourceid=chrome&ie=UTF-8&mstk=AUtExfA7dSXqPHzEKXYymPAFmH4CIdt4Kv6CC2zJxZu6gd0G3HswSwN83WQVeRB7ivBTsSjaH7G8KnGuwj2ihUHEOb9qCteeWrrbv-QIP-91MSHZuoBlkQ_KOLma-qBEtvVzaBU&csui=3&ved=2ahUKEwiYyenrk7iTAxUCRmwGHY24JiQQgK4QegQIARAC) primarily used to treat advanced [renal cell carcinoma](https://www.google.com/search?q=renal+cell+carcinoma&oq=axitinib+Therapeutic+use+%2FDrug+class&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigAdIBCDg5OTBqMGo3qAIAsAIA&sourceid=chrome&ie=UTF-8&mstk=AUtExfA7dSXqPHzEKXYymPAFmH4CIdt4Kv6CC2zJxZu6gd0G3HswSwN83WQVeRB7ivBTsSjaH7G8KnGuwj2ihUHEOb9qCteeWrrbv-QIP-91MSHZuoBlkQ_KOLma-qBEtvVzaBU&csui=3&ved=2ahUKEwiYyenrk7iTAxUCRmwGHY24JiQQgK4QegQIARAD) (RCC). As a targeted anti-cancer agent, it acts by inhibiting vascular endothelial growth factor receptors (VEGFR) to suppress tumor growth and angiogenesis.
Grade	USP
Polymorph	SAB-I, SAB-II, SAB-III, Form-IV & XLI
GTI	Risk assessment report available
Nitrosamines	Risk assessment report available
DMF Availability	USDMF# 30104, EMEA / ASMF 01483
Manufacturing batch size	0.8 kg
Production capacity	Annual capacity is 50 – 60 Kg
Stability data	Available

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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