Dimethyl fumarate

Category API

Details	Specifications
CAS Number	624-49-7
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol.
Synonyms	Dimethyl trans-ethylene dicarboxylate
Chemical Name	Dimethyl (2E)-but-2-enedioate
Common name	Dimethyl fumarate
Therapeutic use	Dimethyl fumarate is used to treat the relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease
Background	Dimethyl fumarate mechanism of action in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress.
Grade	USP
Polymorph	Form-SD
GTI	Risk assessment report available
Nitrosamines	Risk assessment report available
DMF Availability	USDMF# 29655
Manufacturing batch size	140.0 kg
Production capacity	Annual capacity 30 – 40 tonnes
Stability data	Available

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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