Resmetirom

Category Pipeline APIs

Details	Specifications
CAS Number	920509-32-6
Molecular Formula	C17H12Cl2N6O4
Molecular Weight	435.22 g/mol.
Synonyms	2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile
Chemical Name	2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydro pyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
Therapeutic use	Resmetirom to treat adults with noncirrhotic non-alcoholic steatohepatitis (NASH) who have moderate-to-advanced liver fibrosis (F2-F3 stages). It works as a thyroid hormone receptor-beta (THR-?) agonist to reduce fat accumulation in the liver.
Status	Tech pack available
Background	Resmetirom is a first-in-class, oral, liver-directed thyroid hormone receptor-beta agonist approved in 2024 to treat adults with noncirrhotic non-alcoholic steatohepatitis (NASH/MASH) and moderate-to-advanced fibrosis. By targeting liver.it increases fatty acid oxidation and reduces hepatic fat, offering a solution to reduce liver inflammation and fibrosis
Grade	In house
Polymorph	Form I
Storage Temperature	Controlled room temperature (20?C ? 25?C)

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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