Nilotinib

Category API

Details	Specifications
CAS Number	641571-10-0
Molecular Formula	C28H22F3N7O
Molecular Weight	529.527 g/mol.
Synonyms	4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) phenyl] -3- [[4-(3-pyridinyl)-2-pyrimidinyl] amino]-benzamide
Chemical Name	4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) phenyl] -3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino]-benzamide
Common name	Nilotinib
Therapeutic use	Nilotinib (sold under the brand name Tasigna) is used in adults and children at least 1 year old to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).
Background	Nilotinib developed by Novartis, approved by the FDA in 2007, Nilotinib is 10–30 times more potent than imatinib. It targets the BCR-ABL fusion protein (causing CML), as well as KIT and PDGFR receptor tyrosine kinases, inducing apoptosis (cell death) in leukemic cells.
Grade	In-house
Polymorph	Form-B
GTI	Risk assessment report available
Nitrosamines	Risk assessment report available
DMF Availability	USDMF# 36289, EU / ASMF / 00662 / 001
Manufacturing batch size	80.0 Kg
Production capacity	Annual capacity is 4.0 - 6.0 tonnes
Stability data	Available

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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