Shilpa Pharma

ADC Payloads Manufacturers in India

Pharmaceutical ADC Payloads Manufacturing and Supply

Shilpa Pharma is a world-class CDMO offering specialized, large-scale ADC payload manufacturing in India, focused exclusively on bulk production for global pharmaceutical and biotech innovators. With cutting-edge HPAPI facilities, advanced containment systems, and full cGMP compliance, we deliver high-purity and highly potent ADC payloads designed for both clinical and commercial requirements.

As a trusted partner for ADC payload development and bulk supply, we provide complete support — from process optimization and analytical characterization to scalable manufacturing and secure global shipment. Our deep expertise in cytotoxic small-molecule warheads, robust quality systems, and regulatory-ready documentation ensure seamless progress for your ADC programs.

Choose Shilpa Pharma for world-class ADC payload manufacturing in India — delivering uncompromised precision, safety, and bulk-scale reliability for your commercial and clinical pipelines.

Offering Range of ADC Payloads

ADC Payload List

Monomethyl Auristatin E (MMAE) API

CAS No:

474645-27-7

Molecular Weight (M.W):
717.98
Chemical Structure:

Monomethyl Auristatin E (MMAE) is one of the most widely used cytotoxic payloads in Antibody–Drug Conjugates (ADCs). Our MMAE payloads manufacturing ensures high purity, consistent potency, and reliable supply for advanced oncology projects. MMAE is a synthetic antimitotic agent that inhibits tubulin polymerization, making it highly effective in targeted cancer therapies. With state-of-the-art facilities and stringent quality systems, we support global CDMOs and biopharma companies with scalable manufacturing solutions.

MMAF – Monomethyl Auristatin F

CAS No:

745017-94-1

Molecular Weight (M.W):
731.96 g/mol
Chemical Structure:

MMAF is a powerful auristatin-based payload known for its controlled cell permeability and reduced off-target toxicity. Through advanced MMAF payloads manufacturing, we deliver high-quality MMAF suitable for research, development, and commercial ADC programs. Our robust manufacturing process ensures purity, stability, and scalability, supporting both small-batch R&D and large-volume requirements.

VcMMAE – Valine-Citrulline Monomethyl Auristatin E

CAS No:

646502-53-6

Molecular Weight (M.W):
1316.60 g/mol
Chemical Structure:

VcMMAE combines the potency of MMAE with a cleavable valine-citrulline linker, making it a preferred ADC payload worldwide. Our VcMMAE payloads manufacturing process guarantees exceptional batch consistency, improved stability, and optimized linker-payload activity. Ideal for companies developing next-generation targeted therapeutics, our production is backed by GMP systems and international regulatory compliance.

Exatecan Mesylate (Topoisomerase I inhibitor)

CAS No:

169869-90-3

Molecular Weight (M.W):
531.55 g/mol
Chemical Structure:

Exatecan Mesylate is a potent topoisomerase I inhibitor used in modern ADC development for its strong cytotoxic activity. Our Exatecan Mesylate payloads manufacturing follows strict quality standards to provide superior-grade material for oncology research. With optimized synthesis pathways, we offer reliable supply, competitive pricing, and global distribution support.

SN-38 – 7-Ethyl-10-hydroxycamptothecin - Active metabolite of Irinotecan

CAS No:

86639-52-3

Molecular Weight (M.W):
392.42 g/mol
Chemical Structure:

SN-38 is the highly active metabolite of Irinotecan and a powerful topoisomerase I inhibitor used in ADCs and chemotherapeutic formulations. Our SN-38 payloads manufacturing delivers premium-quality SN-38 with high purity and excellent stability profiles. Designed to meet the needs of innovative therapeutic developers, our facility provides scalable and compliant production capabilities.

Irinotecan Hydrochloride (Camptothecin-based Topoisomerase I inhibitor)

CAS No:

100286-90-6

Molecular Weight (M.W):
586.69 g/mol
Chemical Structure:

Irinotecan is a widely used chemotherapy drug and a prodrug of SN-38. As part of our diversified oncology platform, our Irinotecan payloads manufacturing ensures top-tier API quality, reproducible yield, and strict adherence to global regulatory standards. Ideal for formulation companies and CDMOs, we support both clinical and commercial requirements.

Methotrexate (Antimetabolite & Antifolate chemotherapy drug)

CAS No:

59-05-2

Molecular Weight (M.W):
454.44 g/mol
Chemical Structure:

Methotrexate is a trusted antimetabolite and antifolate drug used in cancer treatment and autoimmune therapies. Our Methotrexate payloads manufacturing offers high-purity material with consistent specifications suitable for pharmaceutical applications. We maintain advanced QC processes and reliable production systems to support global supply chains.

Docetaxel (A semisynthetic taxane-class chemotherapeutic agent)

CAS No:

114977-28-5

Molecular Weight (M.W):
807.88 g/mol
Chemical Structure:

Docetaxel is a semisynthetic taxane used extensively in cancer treatment due to its strong antimitotic activity. Through our Docetaxel payloads manufacturing, we ensure high-quality production supported by controlled synthesis and advanced purification technologies. Our manufacturing capabilities cater to research, formulation, and commercial-scale demand.

Paclitaxel (A natural taxane anticancer drug derived from the Pacific yew tree)

CAS No:

33069-62-4

Molecular Weight (M.W):
853.91 g/mol
Chemical Structure:

Paclitaxel is a natural taxane-class anticancer molecule used in various chemotherapy regimens. With our expertise in Paclitaxel payloads manufacturing, we deliver consistently pure and stable material extracted and processed under stringent conditions. Our solutions support pharmaceutical manufacturers, oncology R&D, and global formulations.

Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Dimer-2

CAS No:

145325-57-1

Molecular Weight (M.W):
725.81 g/mol
Chemical Structure:

PBD Dimer-2 (Pyrrolo[2,1-c][1,4]benzodiazepine dimer) is an ultra-potent DNA-binding ADC payload. Our PBD Dimer-2 payloads manufacturing ensures unmatched purity and potency for next-generation ADC development. With advanced synthetic processes and controlled production environments, we meet the demanding requirements of innovative oncology pipelines.

Gemcitabine Hydrochloride

CAS No:

95058-81-4

Molecular Weight (M.W):
299.66 g/mol
Chemical Structure:

Gemcitabine is a nucleoside analog widely used in cancer therapy, particularly for solid tumors. Our Gemcitabine payloads manufacturing guarantees high-quality API suitable for formulations, clinical use, and research applications. We provide reliable supply, strict quality testing, and global delivery support for pharmaceutical partners.

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Shilpa Pharma’s Portfolio of CDMO Payload Manufacturing in India

Shilpa Pharma offers a world-class and highly specialized portfolio of CDMO payload manufacturing in India, dedicated to large-scale and bulk production of high-potency ADC warheads. Our capabilities cover multiple categories of cytotoxic payloads, each manufactured under advanced containment, stringent quality systems, and global regulatory standards.

Our portfolio includes:

✔ Microtubule Inhibitor Payloads
Maytansinoids, auristatins, and related analogs designed for targeted inhibition of cancer cell division.

✔ DNA-Targeting Payloads
High-potency agents such as PBD dimers and calicheamicin derivatives, developed for precision DNA cross-linking and cell-killing activity.

✔ Topoisomerase Inhibitor Payloads
Payloads engineered for controlled DNA replication interference within the ADC mechanism.

✔ Proprietary & Custom Payloads
Co-development and bulk manufacturing of novel or client-specific small-molecule warheads tailored to unique ADC constructs.

Each payload class is supported by comprehensive analytical development, impurity profiling, stability assessment, and process optimization, ensuring consistent quality and reliable bulk supply. With world-class infrastructure and deep scientific expertise, Shilpa Pharma stands as a leading CDMO for ADC payload manufacturing in India, delivering scalable, safe, and commercially ready solutions for global ADC programs.

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