| Details | Specifications | |
|---|---|---|
|
CAS No. |
143782-23-4 |
|
|
Mol. Weight |
228.19 |
|
|
Appearance |
Off white to pale yellow powder |
|
|
Synonyms
|
4-Cyano-3-(trifluoromethyl)phenyl Isothiocyanate |
|
|
Storage |
Preserve in well closed container and store at 2 to 8 °C under nitrogen atmosphere |
|
Disclaimer:Â
The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile (CAS 143782-23-4), also known as 4-cyano-3-(trifluoromethyl)phenyl isothiocyanate, is a specialised aromatic isothiocyanate that functions as a key starting material in the manufacture of second-generation androgen receptor inhibitors. Designated Enzalutamide KSM-III, it is the reagent that installs the entire cyano-trifluoromethylphenyl pharmacophore and supplies the sulphur atom of the thiohydantoin ring, the structural core shared by enzalutamide and apalutamide.
Supplied as an off-white to pale yellow powder with a molecular weight of 228.19, the compound combines three functional features in a compact scaffold: a highly electrophilic isothiocyanate group, an electron-withdrawing trifluoromethyl substituent, and a nitrile. With enzalutamide approaching loss of exclusivity in major markets and generic development programmes advancing accordingly, demand for a secure, high-quality source of this intermediate has risen sharply among API manufacturers preparing for commercial launch.
As established API manufacturers in India, Shilpa Pharma Lifesciences supplies 4-isothiocyanato-2-(trifluoromethyl)benzonitrile as a bulk API intermediate to pharmaceutical manufacturers worldwide. Backed by integrated CDMO services, Shilpa Pharma supports partners from development-scale evaluation through sustained commercial supply.
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile is supplied for use by pharmaceutical manufacturers as a key starting material in the synthesis of androgen receptor inhibitor active pharmaceutical ingredients. In the established route, the electrophilic isothiocyanate carbon is attacked by an amino acid derived amine partner to form a thiourea, which then cyclises to construct the 2-thioxoimidazolidin-4-one, or thiohydantoin, ring that defines this therapeutic class.
Because the intermediate arrives with the cyano and trifluoromethyl substituents already correctly positioned on the aromatic ring, it delivers the complete right-hand fragment of the target molecule in a single convergent step, avoiding several stages of aromatic functionalisation. This makes it central to the manufacture of enzalutamide for metastatic castration-resistant and hormone-sensitive prostate cancer, and equally applicable to apalutamide, which shares the same thiohydantoin architecture.
In a development and manufacturing context, the API intermediate supports process route development and optimisation, analytical method development and validation, impurity profiling and reference standard qualification, process validation batches, and scale-up to commercial campaigns. The material is provided exclusively to qualified pharmaceutical manufacturers, biotechnology companies, and international trading partners for development and manufacturing use under applicable regulatory frameworks.
As a reactive chemical intermediate rather than a finished active, the relevant safety considerations for this compound are occupational and chemical rather than clinical, and they warrant particular attention. Aromatic isothiocyanates are recognised skin and respiratory sensitisers and are strongly irritating to the eyes and mucous membranes, with lachrymatory properties. The material should therefore be handled only by trained personnel under robust containment, with local exhaust ventilation, closed transfer where practicable, and personal protective equipment including chemically resistant gloves, sealed eye protection, and appropriate respiratory protection. Because sensitisation can develop after repeated low-level exposure, minimising all routine contact is important rather than responding only to acute exposure events.
The isothiocyanate group is also moisture sensitive and hydrolyses on contact with water, which degrades assay and generates impurities that carry forward into the downstream synthesis. For this reason the material must be preserved in a well closed container and stored at 2°C to 8°C under a nitrogen atmosphere. Containers should be allowed to equilibrate to ambient temperature before opening to prevent condensation, and should be re-blanketed with nitrogen and resealed promptly after sampling. Complete handling, exposure control, first aid, and disposal guidance is provided in the product’s Safety Data Sheet (SDS), which should be reviewed before use.
This information is provided for scientific and technical reference to pharmaceutical professionals and does not constitute medical advice.
The cost of 4-isothiocyanato-2-(trifluoromethyl)benzonitrile varies according to order volume, required purity specification, packaging including inert-atmosphere requirements, cold-chain shipping arrangements, documentation, and delivery destination. As bulk intermediate pricing is project- and quantity-specific, Shilpa Pharma does not publish standard list pricing for this product.
For current 4-isothiocyanato-2-(trifluoromethyl)benzonitrile pricing, bulk quantity cost estimates, and commercial supply terms, pharmaceutical buyers are invited to contact Shilpa Pharma directly. As a trusted 4-isothiocyanato-2-(trifluoromethyl)benzonitrile supplier and exporter, Shilpa Pharma provides a tailored quotation based on the required quantity, specification, packaging, and documentation needs, along with competitive, cost-effective supply options that support long-term programme economics for both development-scale and commercial-scale requirements.
Shilpa Pharma Lifesciences is one of the most trusted 4-isothiocyanato-2-(trifluoromethyl)benzonitrile manufacturers in India and a full-scale CDMO partner, supplying high-quality actives and intermediates to pharmaceutical companies across more than 80 countries. For this API intermediate, partners choose Shilpa Pharma for:
Partner with Shilpa Pharma, a trusted 4-isothiocyanato-2-(trifluoromethyl)benzonitrile manufacturer and exporter, for a dependable, scalable, and cost-effective global source of this intermediate.
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Please Note: We partner exclusively with pharmaceutical manufacturers, biotech companies, and international trading firms. Minimum order quantities apply*
