| Details | Specifications | |
|---|---|---|
|
CAS No. |
121-71-1 |
|
|
Mol. Weight |
136.15 |
|
|
Appearance |
Light yellow to almost white powder to brown |
|
|
Synonyms
|
1-(3-hydroxyphenyl)ethan-1-one |
|
|
Storage |
Preserve in well closed container and store at controlled room temperature |
|
Disclaimer:Â
The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.
3-Hydroxy acetophenone (CAS 121-71-1), systematically named 1-(3-hydroxyphenyl)ethan-1-one and commonly referred to as 3′-hydroxyacetophenone or m-hydroxyacetophenone, is a versatile aromatic building block widely used as an API intermediate across pharmaceutical synthesis. Its value lies in the combination of two independently reactive handles on a single small scaffold: a phenolic hydroxyl available for etherification, esterification, and carbamoylation, and a methyl ketone available for reductive amination, condensation, and heterocycle formation.
Supplied with a molecular weight of 136.15, the material presents as a powder ranging from light yellow to almost white through to brown, a natural colour variation characteristic of substituted phenols. This dual functionality has made 3-Hydroxy acetophenone a recurring starting material in the manufacture of several therapeutic classes, with documented applications including central nervous system agents such as rivastigmine and sympathomimetic actives such as fenoterol and metaraminol, alongside broader use in specialty chemical and fragrance synthesis.
As established API manufacturers in India, Shilpa Pharma Lifesciences supplies 3-Hydroxy acetophenone as a bulk API intermediate to pharmaceutical and chemical manufacturers worldwide. Backed by integrated CDMO services, Shilpa Pharma supports partners from development-scale evaluation through sustained commercial supply.
3-Hydroxy acetophenone is supplied for use by pharmaceutical and fine chemical manufacturers as a starting material and intermediate in multi-step synthesis. The meta-substitution pattern is the defining feature: it positions the hydroxyl and acetyl groups so that each can be elaborated independently, allowing chemists to build the substituted phenol motif required in a range of drug substances without resorting to lengthy protection and deprotection sequences.
In practice, the ketone is commonly transformed by reduction or reductive amination to give benzylic alcohols and amines, including chiral variants accessed through asymmetric routes, while the phenol is converted into ethers, esters, or carbamates. This complementary reactivity underpins its use in synthesising carbamate-type cholinesterase inhibitors and beta-adrenergic agents, and makes it a valued scaffold in wider heterocyclic and specialty chemical chemistry, including flavour, fragrance, and agrochemical applications.
The material is provided to qualified pharmaceutical manufacturers, chemical companies, and international trading partners for development and manufacturing use under applicable regulatory frameworks.
As a chemical intermediate rather than a finished active, the relevant safety considerations for 3-Hydroxy acetophenone are occupational rather than clinical. In common with substituted phenols and aryl ketones, the material should be treated as an irritant to the eyes, skin, and respiratory tract, and should be handled by trained personnel using appropriate engineering controls, local exhaust ventilation, and personal protective equipment including gloves, eye protection, and respiratory protection where dust may be generated. Contact with skin and inhalation of dust should be avoided.
The material should be preserved in a well closed container and stored at controlled room temperature, protected from light and moisture. Phenolic compounds are susceptible to gradual oxidative discolouration on exposure to air and light, which accounts for the specified appearance range extending to brown; this colour variation does not necessarily indicate a change in assay, and material should be assessed against its agreed specification. Complete handling, exposure control, first aid, and disposal guidance is provided in the product’s Safety Data Sheet (SDS).
This information is provided for scientific and technical reference to professionals and does not constitute medical advice.
The cost of 3-Hydroxy acetophenone varies according to order volume, required purity specification, packaging, documentation, and delivery destination. As bulk intermediate pricing is project- and quantity-specific, Shilpa Pharma does not publish standard list pricing for this product.
For current 3-Hydroxy acetophenone pricing, bulk quantity cost estimates, and commercial supply terms, buyers are invited to contact Shilpa Pharma directly. As a trusted 3-Hydroxy acetophenone supplier and exporter, Shilpa Pharma provides a tailored quotation based on the required quantity, grade, and documentation needs, along with competitive, cost-effective supply options that support long-term programme economics for both development-scale and commercial-scale requirements.
Shilpa Pharma Lifesciences is one of the most trusted 3-Hydroxy acetophenone manufacturers in India and a full-scale CDMO partner, supplying high-quality actives and intermediates to pharmaceutical companies across more than 80 countries. For this API intermediate, partners choose Shilpa Pharma for:
Partner with Shilpa Pharma, a trusted 3-Hydroxy acetophenone manufacturer and exporter, for a dependable, scalable, and cost-effective global source of this intermediate.
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Please Note: We partner exclusively with pharmaceutical manufacturers, biotech companies, and international trading firms. Minimum order quantities apply*
