Nilotinib hydrochloride monohydrate

Category API

Details	Specifications
CAS Number	923288-90-8
Molecular Formula	C28H25ClF3N7O2
Molecular Weight	583.99 g/mol.
Synonyms	4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) phenyl]-3-{[4-(pyridin-3-yl) pyrimidin-2-yl] amino} benzamide hydrochloride monohydrate
Chemical Name	4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoro methyl) phenyl]-3-{[4-(pyridin-3-yl) pyrimidin-2-yl] amino} benzamide hydrochloride monohydrate
Common name	Nilotinib hydrochloride monohydrate
Therapeutic use	Nilotinib is used to treat Philadelphia chromosome-positive (\(Ph+\)) chronic myeloid leukemia (CML).
Background	Nilotinib hydrochloride developed by Novartis, approved by the FDA in 2007, Nilotinib is 10–30 times more potent than imatinib. It targets the BCR-ABL fusion protein (causing CML), as well as KIT and PDGFR receptor tyrosine kinases, inducing apoptosis (cell death) in leukemic cells.
Grade	In-house
Polymorph	Form-B
GTI	Risk assessment report available
Nitrosamines	Risk assessment report available
DMF Availability	-
Manufacturing batch size	-
Production capacity	-
Stability data	Available

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The information provided on this webpage is based on the best available knowledge at the time of publication; however, accuracy and completeness are not guaranteed. Product specifications may change without notice. It is the responsibility of the purchaser or user to verify suitability and compliance. This product is intended for research use only and is not approved for human consumption.

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